Endocrine Abstracts

Gender-specific differences in tumor size at clinical presentation and possible differences in tumor biology make it important to determine treatment outcomes of male patients with bromocriptine [BRC]. We retrospectively analysed treatment response to bromocriptine in 29 male patients with macroprolactinoma (15) and giant macroprolactinoma (14). The duration of treatment was 6-96 months (mean 22.7). Clinical features at presentation included headache (21, 72.4%), visual field ...

A 35 year old woman presented with severe bone pain, body aches, progressive deformities of chest, skull and swelling of hands for two years. Past history included bilateral total hip replacement for fracture of neck of femur one year back. She was normotensive and normo-glycemic. Her dietary consumption of calcium and vitamin D and sun-exposure was adequate. Investigation revealed haemoglobin 5.4gram per deciliter. Serum calcium and serum iPTH levels were elevated at 3.6milim...

Introduction: Deranged mitochondrial biogenesis has been linked to obesity with or without type 2 diabetes but this association has not been reported in non obese type 2 diabetes subjects. This study attempts to identify the various alterations of mitochondrial biogenesis in adipose tissue in obese and non obese type 2 diabetes subjects.Methods & Design: Since type 2 diabetes is associated with elevated serum leptin and depressed serum adiponectin le...

Introduction: Deranged Mitochondrial bioenergetics is a key feature of type 2 diabetes and obesity but its status in non-obese type 2 diabetes patients is not known. The aim of the present study was to assess the status of mitochondrial oxidative phosphorylation and ROS metabolism in subcutaneous adipose tissue isolated from 4 groups of subjects: non-obese subjects with type 2 diabetes (NOT2D), non-obese non diabetic (C), obese non-diabetic (OB) and obese type 2 diabetes subje...

Pseudohypoparathyroidism-1b (PHP-1b) is a genetically and biochemically distinct disorder characterised by selective PTH resistance limited to the kidney and lack of Albright Hereditary Osteodystrophy (AHO). Due to calcium mobilization from bone, patients with PHP-1b may remain asymptomatic and undiagnosed for a long time. Coexistent vitamin D deficiency sometime unmasks the clinical presentation of the disease.A 15-year-old Kuwaiti male presented with s...

The extracellular calcium-sensing receptor (CaR) plays a key role in the body's capacity to maintain a nearly constant level of the extracellular ionized calcium concentration. The parathyroid glands play an especially important role in calcium homeostasis through their capacity to sense even minute perturbations in the extracellular calcium concentration and to respond in ways that will normalize the level of extracellular calcium. In response to hypocalcemia, for example, in...

The development of Leydig cells and steroidogenesis are controlled by activation of luteinizing hormone (LH) receptors by placental HCG during intrauterine life and by pituitary LH after birth. Naturally occurring isolated LH deficiency in man thus provide useful information to understand the intriguing role of this gonadotrophin.The patient was a 23 yr-old man from Afghanistan with a 46, XY karyotype. He presented with absent pubertal development and pr...